Night Renewᴿˣ

Night Renew^Rx is considered the foundation of the Agency nighttime regimen because it helps support skin renewal while you sleep. Use Night Renew^Rx in the evening as prescribed by your medical provider. Apply a thin layer to freshly cleansed skin on your face and neck, then follow with moisturizer. Because Night Renew^Rx is personalized, your medical provider will prescribe the formula and application frequency that is right for your skin, and where it fits within your nighttime routine. Always follow the instructions in your custom treatment plan, especially when first starting or increasing frequency.

Tretinoin* is a prescription retinoid, while retinol is available over the counter. The key difference is how they work in your skin: retinol has to be converted by your skin into its active form before it can get to work, which takes extra steps and reduces its strength along the way. Tretinoin is already in its active form, so your skin can use it right away, which is why it's generally considered more direct and potent. Night Renew^Rx is different from a typical over-the-counter retinol because it's a personalized prescription treatment. Your formula may include tretinoin, along with complementary active ingredients to support your treatment goals. Night Renew^Rx is available in a broader range of tretinoin* strengths—up to 40% stronger and 80% gentler† for a more personalized treatment. *Subject to medical consultation. Not all formulas contain tretinoin. Results may vary. ^†than a retail pharmacy.

Night Renew^Rx is personalized, so your medical provider can take your skin type, sensitivity, and treatment history into account when prescribing your formula and customizing your treatment plan.

If you have sensitive skin, you may be advised to start slowly, use moisturizer consistently, or adjust how often you apply Night Renew^Rx. Let your medical provider know if you have a history of irritation with retinoids or other active ingredients so they can personalize your care accordingly.

During your first month, your skin may need time to adjust to tretinoin*. Dryness, peeling, mild redness, or sensitivity can be common, especially when you first begin treatment or increase how often you use it.

Using moisturizer consistently, wearing sunscreen every day, and following your medical provider’s instructions can help make the adjustment more comfortable. If irritation is worsening or does not improve, message your medical provider. They can offer personalized advice or adjust your formula if needed.

*Subject to medical consultation. Not all formulas contain tretinoin.

Consistency is key. Many people using tretinoin* begin noticing smoother texture and improved tone within 8–12 weeks, with continued improvement over several months of regular use. Tretinoin* works gradually by supporting skin renewal and collagen production over time, so stick with your prescribed routine even if changes feel subtle at first. Your medical provider can adjust your formula as your skin evolves.

*Subject to medical consultation. Not all formulas contain tretinoin. Individual results may vary.

Night Renewᴿˣ is paraben-free, dye-free, fragrance-free, and cruelty-free. Night Renewᴿˣ is also Leaping Bunny–certified.